Bioactives
Drug discovery for tropical diseases is one of the research priorities of Swiss TPH. We have developed a wide range of in vitro assays and in vivo models to identify novel chemical hits and to guide hit-to-lead development. Our credo is to always test against the relevant pathogen species and stage, rather than using surrogate models. The success of this approach is demonstrated by the fact that several of the therapies currently in clinical trials have been developed using our drug discovery platform. Breakthroughs achieved in collaboration with Swiss TPH include novel treatments for Buruli ulcer, human African trypanosomiasis, malaria and soil-transmitted helminths.
Available Drug Efficacy Tests According to Pathogen Species
| Bacteria | ||
|---|---|---|
| Mycobacterium ulcerans | in vitro assays | in vivo assays |
| Protozoa | ||
|---|---|---|
| Babesia divergens | in vitro assays | |
| Babesia microti | in vivo assays | |
| Entamoeba histolytica | in vitro assays | |
| Giardia intestinalis | in vitro assays | |
| Leishmania donovani | in vitro assays | |
| Leishmania infantum | in vitro assays | |
| Plasmodium falciparum | in vitro assays | in vivo assays |
| Plasmodium berghei | ex vivo | in vivo assays |
| Trypanosoma brucei brucei | in vitro assays | in vivo assays |
| Trypanosoma brucei rhodesiense | in vitro assays | in vivo assays |
| Trypanosoma brucei gambiense | in vitro assays | in vivo assays |
| Trypanosoma congolense | in vitro assays | in vivo assays |
| Trypanosoma cruzi | in vitro assays | |
| Trypanosoma evansi | in vitro assays | in vivo assays |
| Trypanosoma vivax | ex vivo assays | in vivo assays |
| Helminths | ||
|---|---|---|
| Ancylostoma ceylanicum | in vitro assays | in vivo assays |
| Echinostoma caproni | in vitro assays | in vivo assays |
| Fasciola hepatica | in vitro assays | in vivo assays |
| Heligmosomoides polygyrus | in vitro assays | in vivo assays |
| Necator americanus | in vitro assays | in vivo assays |
| Schistosoma mansoni | in vitro assays | in vivo assays |
| Schistosoma haematobium | in vitro assays | in vivo assays |
| Trichuris muris | in vitro assays | in vivo assays |
| Divers | ||
|---|---|---|
| several cell lines of Cytotox | in vitro assays |
Range of Arthropod Colonies
We rear a range of mosquito colonies and undertake bioassays in our Arthropod Testing Facility.
| Anopheles gambiae s.s. (Tiassalé) |
| Anopheles gambia s.s. (Kisumu) |
| Anopheles stephensi (STI) |
| Aedes aegypti (Rockefeller) |
| Aedes albopictus (Basiliensis) |
| Culex quinquefasciatus (BG) |
Ticks
| Ornithodoros moubata |
Contacts
