Unit | Medicines Implementation Research

Treatment of severe Malaria

The serious disease malaria is a major burden in tropical and subtropical countries. Although great efforts have been made to control and eliminate malaria, more than  400,000 people still die from it every year. In 2020, nearly half of the world's population was at risk of malaria. Therefore, new treatments are urgently needed.

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Drug and Vaccine Safety

Drug and vaccine safety monitoring needs to continue after marketing authorisation, possibly in an equitable manner. Due to high burden of diseases and lack of resources, especially in resource limited areas safety survaillance is a challenge. We aim to contribute to improve the safe use of medicines in these areas.

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CARAMAL – Community Access to Rectal Artesunate for Malaria

Many children suffering from severe malaria live in poor rural communities with no access to health care. Where parenteral treatment of severe malaria is not available, the World Health Organization recommends treating children less than 6 years old with a single rectal dose artesunate prior to referral to an appropriate facility where the full package of care for severe malaria can be provided. The CARAMAL study investigated the operational feasibility to introduce rectal artesunate into a functioning severe malaria case management system and generates evidence that will guide the design of appropriate strategies for implementation and scale-up of rectal artesunate.

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Artesunate to Treat Severe Malaria

The serious disease malaria is a high burden in tropical and subtropical countries. Although big effort has been done in controlling malaria, it still causes more than  400 000 people each year. Therefore, new treatments are urgently needed. The implementation of the promising drug artesunate was assessed in the MATIAS study.

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