Publications

Baert L, Rudy S, Pellisson M, Doll T, Rocchetti R, Kaiser M, Mäser P, Müller M. Induced pluripotent stem cell-derived human macrophages as an infection model for Leishmania donovani. PLoS Negl Trop Dis. 2024;18(1):e001155. DOI: 10.1371/journal.pntd.0011559

Dupouy B, Donzel M, Roignant M, Charital S, Keumoe R, Yamaryo-Botté Y, Feckler A, Bundschuh M, Bordat Y, Rottmann M, Mäser P, Botté C.Y, Blandin S.A, Besteiro S, Davioud-Charvet E. 3-benzylmenadiones and their heteroaromatic analogues target the apicoplast of apicomplexa parasites: synthesis and bioimaging studies. ACS Infect Dis. 2024;10(10):3553-3576. DOI: 10.1021/acsinfecdis.4c00304

Duwor S, Brites D, Mäser P. Phylogenetic analysis of pyruvate-ferredoxin oxidoreductase, a redox enzyme involved in the pharmacological activation of nitro-based prodrugs in bacteria and protozoa. Biology (Basel). 2024;13(3):178. DOI: 10.3390/biology13030178

Hamid A, Mäser P, Mahmoud A.B. Drug repurposing in the chemotherapy of infectious diseases. Molecules. 2024;29(3):635. DOI: 10.3390/molecules29030635

Hauser D.A, Kaiser M, Mäser P, Albisetti A. Venturicidin A affects the mitochondrial membrane potential and induces kDNA loss in Trypanosoma brucei. Antimicrob Agents Chemother. 2024;68(7):e0167123. DOI: 10.1128/aac.01671-23

Seebacher W, Hoffelner M, Belaj F, Kaiser M, Mäser P, Saf R, Pferschy-Wenzig E.M, Weis R. Tetrahydropyridinylidene ammonium salts with arylalkyl and diarylalkyl substitution and their antiprotozoal activity. Monatsh Chem. 2024;155:73-81. DOI: 10.1007/s00706-023-03142-8

Taylor A.E, Hering M, Elsegood M.R.J, Teat S.J, Weaver G.W, Arroo R.R.J, Kaiser M, Maeser P, Bhambra A.S. Novel 4-[4-(4-methylpiperazin-1-yl)phenyl]-6-arylpyrimidine derivatives and their antitrypanosomal activities against T.brucei. Bioorg Med Chem Lett. 2024;109:129825. DOI: 10.1016/j.bmcl.2024.129825

Trometer N, Pecourneau J, Feng L, Navarro-Huerta J.A, Lazarin-Bidóia D, de Oliveira Silva Lautenschlager S, Maes L, Fortes Francisco A, Kelly J.M, Meunier B, Cal M, Mäser P, Kaiser M, Davioud-Charvet E. Synthesis and anti-Chagas activity profile of a redox-active Lead 3-benzylmenadione revealed by high-content imaging. ACS Infect Dis. 2024;10(5):1808-1838. DOI: 10.1021/acsinfecdis.4c00137

Vahekeni N, Brillatz T, Rahmaty M, Cal M, Keller-Märki S, Rocchetti R, Kaiser M, Sax S, Mattli K, Wolfram E, Marcourt L, Queiroz E.F, Wolfender J.L, Mäser P. Antiprotozoal activity of plants used in the management of sleeping sickness in Angola and bioactivity-guided fractionation of Brasenia schreberi J.F.Gmel and Nymphaea lotus L. Active against T. b rhodesiense. Molecules. 2024;29(7):1611. DOI: 10.3390/molecules29071611

Walesch S, Garcia R, Mahmoud A.B, Panter F, Bollenbach S, Mäser P, Kaiser M, Krug D, Müller R. New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities. Microbiol Spectr. 2024;12(3):e0368923. DOI: 10.1128/spectrum.03689-23

Walz A, Lehmann U, Duthaler U, Mäser P, Wittlin S. In vivo antimalarial efficacy of Artemisia afra powder suspensions. Phytomedicine. 2024;129:155644. DOI: 10.1016/j.phymed.2024.155644

Walz A, Sax S, Scheurer C, Tamasi B, Mäser P, Wittlin S. Incomplete Plasmodium falciparum growth inhibition following piperaquine treatment translates into increased parasite viability in the in vitro parasite reduction ratio assay. Front Cell Infect Microbiol. 2024;14:1396786. DOI: 10.3389/fcimb.2024.1396786

Albisetti A, Hälg S, Zoltner M, Mäser P, Wiedemar N. Suramin action in African trypanosomes involves a RuvB-like DNA helicase. Int J Parasitol Drugs Drug Resist. 2023;23:44-53. DOI: 10.1016/j.ijpddr.2023.09.003

Burri C, Mäser P, Chappuis F. Human African trypanosomiasis. In: Farrar J,Hotez P.J,Junghanss T,Kang G,Lalloo D,White N.J,Garcia P.J, eds. Manson's Tropical Diseases, 623-635. Amsterdam: Elsevier, 2023. DOI: 10.1016/B978-0-7020-7959-7.00051-8

Fesser A, Beilstein S, Kaiser M, Schmidt R.S, Mäser P. Trypanosoma cruzi STIB980: a TcI strain for drug discovery and reverse genetics. Pathogens. 2023;12(10):1217. DOI: 10.3390/pathogens12101217

Hinteregger C, Dolensky J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. Synthesis and antiprotozoal activity of azabicyclo-nonane pyrimidine hybrids. Molecules. 2023;28:307. DOI: 10.3390/molecules28010307

Hochegger P, Hermann T, Dolensky J, Seebacher W, Saf R, Pferschy-Wenzig E.M, Kaiser M, Mäser P, Weis R. Structure-activity relationships and antiplasmodial potencies of novel 3,4-disubstituted 1,2,5-oxadiazoles. Int J Mol Sci. 2023;24(19):14480. DOI: 10.3390/ijms241914480

Mäser P, Bernhard S, Brun R, Burri C, Gagneux S, Hetzel M.W, Kaiser M, Lengeler C, Pluschke G, Reus E, Rottmann M, Utzinger J, Warryn L, Wittlin S, Keiser J. Key contributions by the Swiss Tropical and Public Health Institute towards new and better drugs for tropical diseases. Chimia (Aarau). 2023;77(9):593-606. DOI: 10.2533/chimia.2023.593

Meier L, Antillón M, Burri C, Chitnis N, Endriss Y, Keiser J, Moore S, Müller P, Penny M, Voss T.S, Mäser P, Utzinger J. Repurposing know-how for drug development: case studies from the Swiss Tropical and Public Health Institute. Chimia (Aarau). 2023;77(9):582-592. DOI: 10.2533/chimia.2023.582

Rao S.P.S, Gould M.K, Noeske J, Saldivia M, Jumani R.S, Ng P.S, Rene O, Chen Y.L, Kaiser M, Ritchie R, Francisco A.F, Johnson N, Patra D, Cheung H, Deniston C, Schenk A.D, Cortopassi W.A, Schmidt R.S, Wiedemar N, Thomas B, Palkar R, Ghafar N.A, Manoharan V, Luu C, Gable J.E, Wan K.F, Myburgh E, Mottram J.C, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly J.M, Manjunatha U.H, Mäser P, Jiricek J, Lakshminarayana S.B, Barrett M.P, Diagana T.T. Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science. 2023;380(6652):1349-1356. DOI: 10.1126/science.adh0614

Seebacher W, Kaiser M, Mäser P, Saf R, Pferschy-Wenzig E.M, Weis R. Benzyl- and dibenzyl tetrahydropyridinylidene ammonium salts with antiplasmodial and antitrypanosomal activity. Monatsh Chem. 2023;154:105-114. DOI: 10.1007/s00706-022-03003-w

Sevik Kilicaslan O, Cretton S, Hausmann E, Quirós-Guerrero L, Karimou S, Kaiser M, Mäser P, Christen P, Cuendet M. Antiprotozoal activity of natural products from Nigerien plants used in folk medicine. Front Pharmacol. 2023;14:1190241. DOI: 10.3389/fphar.2023.1190241

Utzinger J,Mäser P, eds. Swiss TPH: 30 years of R&D towards new drugs for tropical diseases. 77. Special issue, 2023. DOI: 10.2533/chimia.2023.570

Walz A, Duffey M, Aljayyoussi G, Sax S, Leroy D, Besson A, Burrows J.N, Cherkaoui-Rbati M.H, Gobeau N, Westwood M-A, Siethoff C, Gamo S, Mäser P, Wittlin S. The Parasite Reduction Ratio (PRR) assay version 2: standardized assessment of Plasmodium falciparum viability after antimalarial treatment in vitro. Pharmaceuticals (Basel). 2023;16(2):163. DOI: 10.3390/ph16020163

Beilstein S, El Phil R, Sahraoui S.S, Scapozza L, Kaiser M, Mäser P. Laboratory selection of trypanosomatid pathogens for drug resistance. Pharmaceuticals (Basel). 2022;15(2):135. DOI: 10.3390/ph15020135

Bernhard S, Kaiser M, Burri C, Mäser P. Fexinidazole for human African trypanosomiasis, the fruit of a successful public-private partnership. Diseases. 2022;10(4):90. DOI: 10.3390/diseases10040090

Dolensky J, Hinteregger C, Leitner A, Seebacher W, Saf R, Belaj F, Mäser P, Kaiser M, Weis R. Antiprotozoal activity of azabicyclo-nonanes linked to tetrazole or sulfonamide cores. Molecules. 2022;27(19):6217. DOI: 10.3390/molecules27196217

Hermann T, Wallner R, Dolensky J, Seebacher W, Pferschy-Wenzig E.-M, Kaiser M, Mäser P, Weis R. New derivatives of the multi-stage active Malaria Box compound MMV030666 and their antiplasmodial potencies. Pharmaceuticals (Basel). 2022;15(12):1503. DOI: 10.3390/ph15121503

Koester D.C, Marx V.M, Williams S, Jiricek J, Dauphinais M, René O, Miller S.L, Zhang L, Patra D, Chen Y.L, Cheung H, Gable J, Lakshminarayana S.B, Osborne C, Galarneau J.R, Kulkarni U, Richmond W, Bretz A, Xiao L, Supek F, Wiesmann C, Honnappa S, Be C, Mäser P, Kaiser M, Ritchie R, Barrett M.P, Diagana T.T, Sarko C, Rao S.P.S. Discovery of novel quinoline-based proteasome inhibitors for human African trypanosomiasis (HAT). J Med Chem. 2022;65:11776−11787. DOI: 10.1021/acs.jmedchem.2c00791

Mäser P. Filariae as organisms. In: Kaminsky R,Geary T,Selter P, eds. Human and animal filariases: landscape, challenges, and control, 17-32: Wiley, 2022

Mousavi A, Foroumadi P, Emamgholipour Z, Mäser P, Kaiser M, Foroumadi A. 2-(Nitroaryl)-5-substituted-1,3,4-thiadiazole derivatives with antiprotozoal activities: in vitro and in vivo study. Molecules. 2022;27:5559. DOI: 10.3390/molecules27175559

Scheiber N, Blaser G, Pferschy-Wenzig E.M, Kaiser M, Mäser P, Presser A. Efficient oxidative dearomatisations of substituted phenols using hypervalent iodine (iii) reagents and antiprotozoal evaluation of the resulting cyclohexadienones against T. b. rhodesiense and P. falciparum strain NF54. Molecules. 2022;27(19):6559. DOI: 10.3390/molecules27196559

Sevik Kilicaslan O, Cretton S, Quiros-Guerrero L, Bella M.A, Kaiser M, Mäser P, Ndongo J.T, Cuendet M. Isolation and structural elucidation of compounds from Pleiocarpa bicarpellata and their in vitro antiprotozoal activity. Molecules. 2022;27(7):2200. DOI: 10.3390/molecules27072200

Barth-Jaeggi T, Mäser P. Leishmaniasis in Europe and Central Asia: epidemiology, impact of habitat and lifestyle changes, HIV coinfection. In: Steinmann P,Utzinger J, eds. Neglected tropical diseases - Europe and Central Asia, 83-100. Cham: Springer, 2021. DOI: 10.1007/978-3-030-84224-6_5

Boberg M, Cal M, Kaiser M, Jansson-Lofmark R, Mäser P, Ashton M. Enantiospecific antitrypanosomal in vitro activity of eflornithine. PLoS Negl Trop Dis. 2021;15(7):e0009583. DOI: 10.1371/journal.pntd.0009583

Brand M, Wang L, Agnello S, Gazzola S, Gall F.M, Raguz L, Kaiser M, Schmidt R.S, Ritschl A, Jelk J, Hemphill A, Mäser P, Butikofer P, Adams M, Riedl R. Antiprotozoal structure-activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action. Angew Chem Int Ed Engl. 2021;60(28):15613-15621. DOI: 10.1002/anie.202102153

Cretton S, Genta-Jouve G, Kaiser M, Mäser P, Muñoz O, Bürgi T, Cuendet M, Christen P. Hygroline derivatives from Schizanthus tricolor and their anti-trypanosomatid and antiplasmodial activities. Phytochemistry. 2021;192:112957. DOI: 10.1016/j.phytochem.2021.112957

Fesser A, Kaiser M, Mäser P. Neue Parameter für die Wirkstofftestung gegen Trypanosoma cruzi. Biospektrum (Heidelb). 2021;27(2):168-170. DOI: 10.1007/s12268-021-1554-z

Flittner D, Kaiser M, Mäser P, Lopes N.P, Schmidt T.J. The alkaloid-enriched fraction of Pachysandra terminalis (Buxaceae) shows prominent activity against Trypanosoma brucei rhodesiense. Molecules. 2021;26(3):591. DOI: 10.3390/molecules26030591

Greve H.L, Kaiser M, Mäser P, Schmidt T.J. Boswellic acids show in vitro activity against Leishmania donovani. Molecules. 2021;26(12):3651. DOI: 10.3390/molecules26123651