Publications

Baert L, Rudy S, Pellisson M, Doll T, Rocchetti R, Kaiser M, Mäser P, Müller M. Induced pluripotent stem cell-derived human macrophages as an infection model for Leishmania donovani. PLoS Negl Trop Dis. 2024;18(1):e001155. DOI: 10.1371/journal.pntd.0011559

Dupouy B, Donzel M, Roignant M, Charital S, Keumoe R, Yamaryo-Botté Y, Feckler A, Bundschuh M, Bordat Y, Rottmann M, Mäser P, Botté C.Y, Blandin S.A, Besteiro S, Davioud-Charvet E. 3-benzylmenadiones and their heteroaromatic analogues target the apicoplast of apicomplexa parasites: synthesis and bioimaging studies. ACS Infect Dis. 2024;10(10):3553-3576. DOI: 10.1021/acsinfecdis.4c00304

Duwor S, Brites D, Mäser P. Phylogenetic analysis of pyruvate-ferredoxin oxidoreductase, a redox enzyme involved in the pharmacological activation of nitro-based prodrugs in bacteria and protozoa. Biology (Basel). 2024;13(3):178. DOI: 10.3390/biology13030178

Hamid A, Mäser P, Mahmoud A.B. Drug repurposing in the chemotherapy of infectious diseases. Molecules. 2024;29(3):635. DOI: 10.3390/molecules29030635

Hauser D.A, Kaiser M, Mäser P, Albisetti A. Venturicidin A affects the mitochondrial membrane potential and induces kDNA loss in Trypanosoma brucei. Antimicrob Agents Chemother. 2024;68(7):e0167123. DOI: 10.1128/aac.01671-23

Seebacher W, Hoffelner M, Belaj F, Kaiser M, Mäser P, Saf R, Pferschy-Wenzig E.M, Weis R. Tetrahydropyridinylidene ammonium salts with arylalkyl and diarylalkyl substitution and their antiprotozoal activity. Monatsh Chem. 2024;155:73-81. DOI: 10.1007/s00706-023-03142-8

Taylor A.E, Hering M, Elsegood M.R.J, Teat S.J, Weaver G.W, Arroo R.R.J, Kaiser M, Maeser P, Bhambra A.S. Novel 4-[4-(4-methylpiperazin-1-yl)phenyl]-6-arylpyrimidine derivatives and their antitrypanosomal activities against T.brucei. Bioorg Med Chem Lett. 2024;109:129825. DOI: 10.1016/j.bmcl.2024.129825

Trometer N, Pecourneau J, Feng L, Navarro-Huerta J.A, Lazarin-Bidóia D, de Oliveira Silva Lautenschlager S, Maes L, Fortes Francisco A, Kelly J.M, Meunier B, Cal M, Mäser P, Kaiser M, Davioud-Charvet E. Synthesis and anti-Chagas activity profile of a redox-active Lead 3-benzylmenadione revealed by high-content imaging. ACS Infect Dis. 2024;10(5):1808-1838. DOI: 10.1021/acsinfecdis.4c00137

Vahekeni N, Brillatz T, Rahmaty M, Cal M, Keller-Märki S, Rocchetti R, Kaiser M, Sax S, Mattli K, Wolfram E, Marcourt L, Queiroz E.F, Wolfender J.L, Mäser P. Antiprotozoal activity of plants used in the management of sleeping sickness in Angola and bioactivity-guided fractionation of Brasenia schreberi J.F.Gmel and Nymphaea lotus L. Active against T. b rhodesiense. Molecules. 2024;29(7):1611. DOI: 10.3390/molecules29071611

Walesch S, Garcia R, Mahmoud A.B, Panter F, Bollenbach S, Mäser P, Kaiser M, Krug D, Müller R. New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities. Microbiol Spectr. 2024;12(3):e0368923. DOI: 10.1128/spectrum.03689-23

Walz A, Lehmann U, Duthaler U, Mäser P, Wittlin S. In vivo antimalarial efficacy of Artemisia afra powder suspensions. Phytomedicine. 2024;129:155644. DOI: 10.1016/j.phymed.2024.155644

Walz A, Sax S, Scheurer C, Tamasi B, Mäser P, Wittlin S. Incomplete Plasmodium falciparum growth inhibition following piperaquine treatment translates into increased parasite viability in the in vitro parasite reduction ratio assay. Front Cell Infect Microbiol. 2024;14:1396786. DOI: 10.3389/fcimb.2024.1396786

Albisetti A, Hälg S, Zoltner M, Mäser P, Wiedemar N. Suramin action in African trypanosomes involves a RuvB-like DNA helicase. Int J Parasitol Drugs Drug Resist. 2023;23:44-53. DOI: 10.1016/j.ijpddr.2023.09.003

Burri C, Mäser P, Chappuis F. Human African trypanosomiasis. In: Farrar J,Hotez P.J,Junghanss T,Kang G,Lalloo D,White N.J,Garcia P.J, eds. Manson's Tropical Diseases, 623-635. Amsterdam: Elsevier, 2023. DOI: 10.1016/B978-0-7020-7959-7.00051-8

Fesser A, Beilstein S, Kaiser M, Schmidt R.S, Mäser P. Trypanosoma cruzi STIB980: a TcI strain for drug discovery and reverse genetics. Pathogens. 2023;12(10):1217. DOI: 10.3390/pathogens12101217

Hinteregger C, Dolensky J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. Synthesis and antiprotozoal activity of azabicyclo-nonane pyrimidine hybrids. Molecules. 2023;28:307. DOI: 10.3390/molecules28010307

Hochegger P, Hermann T, Dolensky J, Seebacher W, Saf R, Pferschy-Wenzig E.M, Kaiser M, Mäser P, Weis R. Structure-activity relationships and antiplasmodial potencies of novel 3,4-disubstituted 1,2,5-oxadiazoles. Int J Mol Sci. 2023;24(19):14480. DOI: 10.3390/ijms241914480

Mäser P, Bernhard S, Brun R, Burri C, Gagneux S, Hetzel M.W, Kaiser M, Lengeler C, Pluschke G, Reus E, Rottmann M, Utzinger J, Warryn L, Wittlin S, Keiser J. Key contributions by the Swiss Tropical and Public Health Institute towards new and better drugs for tropical diseases. Chimia (Aarau). 2023;77(9):593-606. DOI: 10.2533/chimia.2023.593

Meier L, Antillón M, Burri C, Chitnis N, Endriss Y, Keiser J, Moore S, Müller P, Penny M, Voss T.S, Mäser P, Utzinger J. Repurposing know-how for drug development: case studies from the Swiss Tropical and Public Health Institute. Chimia (Aarau). 2023;77(9):582-592. DOI: 10.2533/chimia.2023.582

Rao S.P.S, Gould M.K, Noeske J, Saldivia M, Jumani R.S, Ng P.S, Rene O, Chen Y.L, Kaiser M, Ritchie R, Francisco A.F, Johnson N, Patra D, Cheung H, Deniston C, Schenk A.D, Cortopassi W.A, Schmidt R.S, Wiedemar N, Thomas B, Palkar R, Ghafar N.A, Manoharan V, Luu C, Gable J.E, Wan K.F, Myburgh E, Mottram J.C, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly J.M, Manjunatha U.H, Mäser P, Jiricek J, Lakshminarayana S.B, Barrett M.P, Diagana T.T. Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science. 2023;380(6652):1349-1356. DOI: 10.1126/science.adh0614

Seebacher W, Kaiser M, Mäser P, Saf R, Pferschy-Wenzig E.M, Weis R. Benzyl- and dibenzyl tetrahydropyridinylidene ammonium salts with antiplasmodial and antitrypanosomal activity. Monatsh Chem. 2023;154:105-114. DOI: 10.1007/s00706-022-03003-w

Sevik Kilicaslan O, Cretton S, Hausmann E, Quirós-Guerrero L, Karimou S, Kaiser M, Mäser P, Christen P, Cuendet M. Antiprotozoal activity of natural products from Nigerien plants used in folk medicine. Front Pharmacol. 2023;14:1190241. DOI: 10.3389/fphar.2023.1190241

Utzinger J,Mäser P, eds. Swiss TPH: 30 years of R&D towards new drugs for tropical diseases. 77. Special issue, 2023. DOI: 10.2533/chimia.2023.570

Walz A, Duffey M, Aljayyoussi G, Sax S, Leroy D, Besson A, Burrows J.N, Cherkaoui-Rbati M.H, Gobeau N, Westwood M-A, Siethoff C, Gamo S, Mäser P, Wittlin S. The Parasite Reduction Ratio (PRR) assay version 2: standardized assessment of Plasmodium falciparum viability after antimalarial treatment in vitro. Pharmaceuticals (Basel). 2023;16(2):163. DOI: 10.3390/ph16020163

Beilstein S, El Phil R, Sahraoui S.S, Scapozza L, Kaiser M, Mäser P. Laboratory selection of trypanosomatid pathogens for drug resistance. Pharmaceuticals (Basel). 2022;15(2):135. DOI: 10.3390/ph15020135

Bernhard S, Kaiser M, Burri C, Mäser P. Fexinidazole for human African trypanosomiasis, the fruit of a successful public-private partnership. Diseases. 2022;10(4):90. DOI: 10.3390/diseases10040090

Dolensky J, Hinteregger C, Leitner A, Seebacher W, Saf R, Belaj F, Mäser P, Kaiser M, Weis R. Antiprotozoal activity of azabicyclo-nonanes linked to tetrazole or sulfonamide cores. Molecules. 2022;27(19):6217. DOI: 10.3390/molecules27196217

Hermann T, Wallner R, Dolensky J, Seebacher W, Pferschy-Wenzig E.-M, Kaiser M, Mäser P, Weis R. New derivatives of the multi-stage active Malaria Box compound MMV030666 and their antiplasmodial potencies. Pharmaceuticals (Basel). 2022;15(12):1503. DOI: 10.3390/ph15121503

Koester D.C, Marx V.M, Williams S, Jiricek J, Dauphinais M, René O, Miller S.L, Zhang L, Patra D, Chen Y.L, Cheung H, Gable J, Lakshminarayana S.B, Osborne C, Galarneau J.R, Kulkarni U, Richmond W, Bretz A, Xiao L, Supek F, Wiesmann C, Honnappa S, Be C, Mäser P, Kaiser M, Ritchie R, Barrett M.P, Diagana T.T, Sarko C, Rao S.P.S. Discovery of novel quinoline-based proteasome inhibitors for human African trypanosomiasis (HAT). J Med Chem. 2022;65:11776−11787. DOI: 10.1021/acs.jmedchem.2c00791

Mäser P. Filariae as organisms. In: Kaminsky R,Geary T,Selter P, eds. Human and animal filariases: landscape, challenges, and control, 17-32: Wiley, 2022

Mousavi A, Foroumadi P, Emamgholipour Z, Mäser P, Kaiser M, Foroumadi A. 2-(Nitroaryl)-5-substituted-1,3,4-thiadiazole derivatives with antiprotozoal activities: in vitro and in vivo study. Molecules. 2022;27:5559. DOI: 10.3390/molecules27175559

Scheiber N, Blaser G, Pferschy-Wenzig E.M, Kaiser M, Mäser P, Presser A. Efficient oxidative dearomatisations of substituted phenols using hypervalent iodine (iii) reagents and antiprotozoal evaluation of the resulting cyclohexadienones against T. b. rhodesiense and P. falciparum strain NF54. Molecules. 2022;27(19):6559. DOI: 10.3390/molecules27196559

Sevik Kilicaslan O, Cretton S, Quiros-Guerrero L, Bella M.A, Kaiser M, Mäser P, Ndongo J.T, Cuendet M. Isolation and structural elucidation of compounds from Pleiocarpa bicarpellata and their in vitro antiprotozoal activity. Molecules. 2022;27(7):2200. DOI: 10.3390/molecules27072200

Barth-Jaeggi T, Mäser P. Leishmaniasis in Europe and Central Asia: epidemiology, impact of habitat and lifestyle changes, HIV coinfection. In: Steinmann P,Utzinger J, eds. Neglected tropical diseases - Europe and Central Asia, 83-100. Cham: Springer, 2021. DOI: 10.1007/978-3-030-84224-6_5

Boberg M, Cal M, Kaiser M, Jansson-Lofmark R, Mäser P, Ashton M. Enantiospecific antitrypanosomal in vitro activity of eflornithine. PLoS Negl Trop Dis. 2021;15(7):e0009583. DOI: 10.1371/journal.pntd.0009583

Brand M, Wang L, Agnello S, Gazzola S, Gall F.M, Raguz L, Kaiser M, Schmidt R.S, Ritschl A, Jelk J, Hemphill A, Mäser P, Butikofer P, Adams M, Riedl R. Antiprotozoal structure-activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action. Angew Chem Int Ed Engl. 2021;60(28):15613-15621. DOI: 10.1002/anie.202102153

Cretton S, Genta-Jouve G, Kaiser M, Mäser P, Muñoz O, Bürgi T, Cuendet M, Christen P. Hygroline derivatives from Schizanthus tricolor and their anti-trypanosomatid and antiplasmodial activities. Phytochemistry. 2021;192:112957. DOI: 10.1016/j.phytochem.2021.112957

Fesser A, Kaiser M, Mäser P. Neue Parameter für die Wirkstofftestung gegen Trypanosoma cruzi. Biospektrum (Heidelb). 2021;27(2):168-170. DOI: 10.1007/s12268-021-1554-z

Flittner D, Kaiser M, Mäser P, Lopes N.P, Schmidt T.J. The alkaloid-enriched fraction of Pachysandra terminalis (Buxaceae) shows prominent activity against Trypanosoma brucei rhodesiense. Molecules. 2021;26(3):591. DOI: 10.3390/molecules26030591

Greve H.L, Kaiser M, Mäser P, Schmidt T.J. Boswellic acids show in vitro activity against Leishmania donovani. Molecules. 2021;26(12):3651. DOI: 10.3390/molecules26123651

Hermann T, Hochegger P, Dolensky J, Seebacher W, Pferschy-Wenzig E.M, Saf R, Kaiser M, Mäser P, Weis R. Synthesis and structure-activity relationships of new 2-phenoxybenzamides with antiplasmodial activity. Pharmaceuticals (Basel). 2021;14:1109. DOI: 10.3390/ph14111109

Hermann T, Hochegger P, Dolensky J, Seebacher W, Saf R, Kaiser M, Mäser P, Weis R. New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities. Pharmaceuticals (Basel). 2021;14(5):412. DOI: 10.3390/ph14050412

Hitz E, Wiedemar N, Passecker A, Graça B.A.S, Scheurer C, Wittlin S, Brancucci N.M.B, Vakonakis I, Mäser P, Voss T.S. The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites. PLoS Biol. 2021;19(12):e3001483. DOI: 10.1371/journal.pbio.3001483

Hochegger P, Dolensky J, Seebacher W, Saf R, Kaiser M, Mäser P, Weis R. 8-amino-6-methoxyquinoline-tetrazole hybrids: Impact of linkers on antiplasmodial activity. Molecules. 2021;26(18):5530. DOI: 10.3390/molecules26185530

Hoffelner M.H, Seebacher W, Kaiser M, Mäser P, Pferschy-Wenzig E.M, Saf R, Belaj F, Kretschmer N, Alajlani M, Brantner A, Bauer R, Weis R. Unexpected ring‑opening of 2,3‑dihydropyridines. Monatsh Chem. 2021;152:1347–1359. DOI: 10.1007/s00706-021-02847-y

Llurba Montesino N, Kaiser M, Mäser P, Schmidt T.J. Nucleic acid amplification techniques for the detection of Schistosoma mansoni infection in humans and the intermediate snail host: a structured review and meta-analysis of diagnostic accuracy. Molecules. 2021;26(11):3226. DOI: 10.3390/molecules26113226

Mahmoud A.B, Abd Algaffar S, van de Sande W, Khalid S, Kaiser M, Mäser P. Niclosamide is active in vitro against mycetoma pathogens. Molecules. 2021;26(13):4005. DOI: 10.3390/molecules26134005

Petritsch M, Seebacher W, Mohsin N.U, Dolensky J, Hochegger P, Kaiser M, Mäser P, Belaj F, Saf R, Kretschmer N, Alajlani M, Brantner A, Bauer R, Schuhly W, Weis R. Preparation of new 1,3-dibenzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. Eur J Med Chem. 2021;210:112969. DOI: 10.1016/j.ejmech.2020.112969

Rocha-Hasler M, de Oliveira G.M, da Gama A.N, Fiuza L.F.A, Fesser A.F, Cal M, Rocchetti R, Peres R.B, Guan X.L, Kaiser M, Soeiro M.N.C, Mäser P. Combination with tomatidine improves the potency of posaconazole against Trypanosoma cruzi. Front Cell Infect Microbiol. 2021;11:617917. DOI: 10.3389/fcimb.2021.617917

Seebacher W, Mohsin N.U.A, Dolensky J, Hochegger P, Kaiser M, Mäser P, Saf R, Schuster D, Temml V, Weis R. Modifications and hybrids of 1,2,3,4‑tetrahydropyridinium salts and their antiprotozoal potencies. Monatsh Chem. 2021;152:1347–1359. DOI: 10.1007/s00706-021-02847-y

Szabó L.U, Kaiser M, Mäser P, Schmidt T.J. Antiprotozoal Nor-triterpene alkaloids from Buxus sempervirens L. Antibiotics (Basel). 2021;10(6):696. DOI: 10.3390/antibiotics10060696

Szabó L.U, Kaiser M, Mäser P, Schmidt T.J. Identification of antiprotozoal compounds from Buxus sempervirens L. by PLS-prediction. Molecules. 2021;26(20):6181. DOI: 10.3390/molecules26206181

Wittlin S, Mäser P. From magic bullet to magic bomb: reductive bioactivation of antiparasitic agents. ACS Infect Dis. 2021;7(10):2777-2786. DOI: 10.1021/acsinfecdis.1c00118

Zeelen J, van Straaten M, Verdi J, Hempelmann A, Hashemi H, Perez K, Jeffrey P.D, Hälg S, Wiedemar N, Mäser P, Papavasiliou F.N, Stebbins C.E. Structure of trypanosome coat protein VSGsur and function in suramin resistance. Nat Microbiol. 2021;6(3):392-400. DOI: 10.1038/s41564-020-00844-1

Cretton S, Kaiser M, Karimou S, Ebrahimi S.N, Mäser P, Cuendet M, Christen P. Pyridine-4(1H)-one alkaloids from Waltheria indica as antitrypanosomatid agents. J Nat Prod. 2020;83(11):3363-3371. DOI: 10.1021/acs.jnatprod.0c00671

Dawidowski M, Kalel V.C, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko I.V, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz G.M. Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 protein-protein interaction with trypanocidal activity. J Med Chem. 2020;63(2):847-879. DOI: 10.1021/acs.jmedchem.9b01876

Dickie E.A, Giordani F, Gould M.K, Mäser P, Burri C, Mottram J.C, Rao S.P.S, Barrett M.P. New drugs for human African trypanosomiasis: a twenty first century success story. Trop Med Infect Dis. 2020;5:29. DOI: 10.3390/tropicalmed5010029

Fesser A.F, Braissant O, Olmo F, Kelly J.M, Mäser P, Kaiser M. Non-invasive monitoring of drug action: a new live in vitro assay design for Chagas' disease drug discovery. PLoS Negl Trop Dis. 2020;14(7):e0008487. DOI: 10.1371/journal.pntd.0008487

Hoffelner M, Hassan U, Seebacher W, Dolensky J, Hochegger P, Kaiser M, Mäser P, Saf R, Weis R. New 2‑aminopyrimidine derivatives and their antitrypanosomal and antiplasmodial activities. Monatsh Chem. 2020;151:1375–1385

Kaiser M, Mäser P. In vitro drug efficacy testing against Trypanosoma brucei. In: Michels P.A.M,Ginger M.L,Zilberstein D, eds. Trypanosomatids: methods and protocols. 2116, 781-789. New York: Springer, 2020. DOI: 10.1007/978-1-0716-0294-2_46

Mahmoud A.B, Danton O, Kaiser M, Han S, Moreno A, Abd Algaffar S, Khalid S, Oh W.K, Hamburger M, Mäser P. Lignans, amides, and saponins from Haplophyllum tuberculatum and their antiprotozoal activity. Molecules. 2020;25(12):2825. DOI: 10.3390/molecules25122825

Mahmoud A.B, Danton O, Kaiser M, Khalid S, Hamburger M, Mäser P. HPLC-based activity profiling for antiprotozoal compounds in Croton gratissimus and Cuscuta hyalina. Front Pharmacol. 2020;11:1246. DOI: 10.3389/fphar.2020.01246

Mahmoud A.B, Mäser P, Kaiser M, Hamburger M, Khalid S. Mining Sudanese medicinal plants for antiprotozoal agents. Front Pharmacol. 2020;11:865. DOI: 10.3389/fphar.2020.00865

Rao S.P.S, Lakshminarayana S.B, Jiricek J, Kaiser M, Ritchie R, Myburgh E, Supek F, Tuntland T, Nagle A, Molteni V, Mäser P, Mottram J.C, Barrett M.P, Diagana T.T. Anti-trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of African trypanosomiasis. Trop Med Infect Dis. 2020;5:28. DOI: 10.3390/tropicalmed5010028

Vahekeni N, Neto P.M, Kayimbo M.K, Mäser P, Theophile J, da Costa E, Falquet J, van Eeuwijk P. Use of herbal remedies in the management of sleeping sickness in four northern provinces of Angola. J Ethnopharmacol. 2020;256:112382. DOI: 10.1016/j.jep.2019.112382

Wiedemar N, Hauser D.A, Mäser P. One hundred years of Suramin. Antimicrob Agents Chemother. 2020;64(3):e01168-19. DOI: 10.1128/AAC.01168-19

Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig J.A, Pisco J.P, Peet C, Dranow D.M, Robinson D.A, Jansen C, Norcross N.R, Vinayak S, Anderson M, Brooks C.F, Cooper C.A, Damerow S, Delves M, Dowers K, Duffy J, Edwards T.E, Hallyburton I, Horst B.G, Hulverson M.A, Ferguson L, Jiménez-Díaz M.B, Jumani R.S, Lorimer D.D, Love M.S, Maher S, Matthews H, McNamara C.W, Miller P, O'Neill S, Ojo K.K, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz L.M, Scullion P, Sharma A, Shepherd S.M, Shishikura Y, Simeons F.R.C, Stebbins E.E, Stojanovski L, Straschil U, Tamaki F.K, Tamjar J, Torrie L.S, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo F.J, Mäser P, Kyle D.E, Winzeler E.A, Myler P.J, Wyatt P.G, Floyd D, Matthews D, Sharma A, Striepen B, Huston C.D, Gray D.W, Fairlamb A.H, Pisliakov A.V, Walpole C, Read K.D, Van Voorhis W.C, Gilbert I.H. Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proc Natl Acad Sci USA. 2019;116(14):7015-7020. DOI: 10.1073/pnas.1814685116

Hochegger P, Faist J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity. Bioorg Med Chem. 2019;27(10):2052-2065. DOI: 10.1016/j.bmc.2019.03.061

Hochegger P, Faist J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. Antiprotozoal activities of tetrazole-quinolines with aminopiperidine linker. Med Chem. 2019;15(4):409-416. DOI: 10.2174/1573406414666181015115101

Hoffelner M, Petritsch M, Ahmad S, Seebacher W, Dolensky J, Hochegger P, Kaiser M, Mäser P, Saf R, Weis R. New derivatives of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. Monatsh Chem. 2019;150(11):1959-1972. DOI: 10.1007/s00706-019-02509-0

Jourdan J, Walz A, Matile H, Schmidt A, Wu J, Wang X, Dong Y, Vennerstrom J.L, Schmidt R.S, Wittlin S, Mäser P. Stochastic protein alkylation by antimalarial peroxides. ACS Infect Dis. 2019;5(12):2067-2075. DOI: 10.1021/acsinfecdis.9b00264

Mäser P. Parasiten machen Geschichte. In: Bregy C,Buschle M,Settelen-Trees D, eds. Gespräche im Garten: Kultur - Natur - Gutes Leben: , 127-131. Basel: Christoph Merian Verlag, 2019

Mohsin N.U.A, Seebacher W, Hochegger P, Faist J, Saf R, Kaiser M, Mäser P, Weis R. Synthesis of new 1-benzyl tetrahydropyridin-4-ylidene piperidinium salts and their antiplasmodial and antitrypanosomal activities. Med Chem Res. 2019;28(5):742-753. DOI: 10.1007/s00044-019-02331-7

Rao S.P.S, Barrett M.P, Dranoff G, Faraday C.J, Gimpelewicz C.R, Hailu A, Jones C.L, Kelly J.M, Lazdins-Helds J.K, Mäser P, Mengel J, Mottram J.C, Mowbray C.E, Sacks D.L, Scott P, Spath G.F, Tarleton R.L, Spector J.M, Diagana T.T. Drug discovery for kinetoplastid diseases: future directions. ACS Infect Dis. 2019;5(2):152-157. DOI: 10.1021/acsinfecdis.8b00298

Saccoliti F, Madia V.N, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet Alvarez C.M, Jennings G.K, Podust L.M, Pepe G, Cirilli R, Faggi C, Di Marco A, Battista M.R, Summa V, Costi R, Di Santo R. Design, synthesis, and biological evaluation of new 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole derivatives as antiprotozoal agents. J Med Chem. 2019;62(3):1330-1347. DOI: 10.1021/acs.jmedchem.8b01464

Walz A, Leroy D, Andenmatten N, Mäser P, Wittlin S. Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay. Malar J. 2019;18:427. DOI: 10.1186/s12936-019-3056-8

Wiedemar N, Zwyer M, Zoltner M, Cal M, Field M.C, Mäser P. Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in Trypanosoma brucei. FASEB Bioadv. 2019;1(10):595-608. DOI: 10.1096/fba.2019-00033

Grogg M, Hilvert D, Ebert M.O, Beck A.K, Seebach D, Kurth F, Dittrich P.S, Sparr C, Wittlin S, Rottmann M, Mäser P. Cell penetration, herbicidal activity, and in-vivo-toxicity of oligo-arginine derivatives and of novel guanidinium-rich compounds derived from the biopolymer cyanophycin. Helvetica Chimica Acta. 2018;101(10):e1800112. DOI: 10.1002/hlca.201800112

Gysin M, Braissant O, Gillingwater K, Brun R, Mäser P, Wenzler T. Isothermal microcalorimetry – a quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time. Int J Parasitol Drugs Drug Resist. 2018;8(2):159-164. DOI: 10.1016/j.ijpddr.2018.03.003

Kalel V.C, Mäser P, Sattler M, Erdmann R, Popowicz G.M. Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development. Curr Opin Microbiol. 2018;46:116-122. DOI: 10.1016/j.mib.2018.11.003