A new chemotype with promise against <em>Trypanosoma cruzi</em> (Publications)
Pyridyl benzamide 2 is a potent inhibitor of Trypanosoma cruzi, but not other protozoan parasites, and had a selectivity-index of > /=10. The initial structure-activity relationship (SAR) indicates th
Atopy modifies the association between inhaled corticosteroid use and lung function decline in patients with asthma (Publications)
BACKGROUND: Inhaled corticosteroids (ICSs) are the mainstay of asthma treatment, but response to medication is variable. Patients with allergic inflammation generally show a better short-term response
Non-randomized studies using causal-modelling may give different answers than RCTs: a meta-epidemiological study (Publications)
OBJECTIVES: To evaluate how estimated treatment effects agree between non-randomized studies using causal modelling with marginal structural models (MSM-studies) and randomized trials (RCTs). STUDY DE
Safety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in... (Publications)
BACKGROUND: We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducte
The <em>Plasmodium falciparum</em> Hsp70-x chaperone assists the heat stress response of the malaria parasite (Publications)
Plasmodium falciparum is the most lethal of human-infective malaria parasites. A hallmark of P. falciparum malaria is extensive remodeling of host erythrocytes by the parasite, which facilitates the d
The catastrophic and impoverishing effects of out-of-pocket healthcare payments in Kenya, 2018 (Publications)
Introduction: Progress towards effective service coverage and financial protection-the two dimensions of Universal Health Coverage (UHC)-has been limited in Kenya in the last decade. The government of