Effects of filter choice in GT3X accelerometer assessments of free-living activity (Publications)
PURPOSE: Actigraph accelerometers are widely used devices to objectively assess physical activity. The GT3X version has two filter options to be selected prior to data assessment (normal and low frequ
Predictors of methacholine responsiveness in a general population (Publications)
OBJECTIVE: Methacholine responsiveness is an end point widely used in epidemiologic studies of asthma. This study aims to quantify the relative importance of different predictors of responsiveness suc
Glutathione S-transferase polymorphisms, passive smoking, obesity, and heart rate variability in nonsmokers (Publications)
BACKGROUND: Disturbances of heart rate variability (HRV) may represent one pathway by which second-hand smoke (SHS) and air pollutants affect cardiovascular morbidity and mortality. The mechanisms are
Ten-year follow-up of cluster-based asthma phenotypes in adults: a pooled analysis of three cohorts (Publications)
Rationale: The temporal stability of adult asthma phenotypes identified using clustering methods has never been addressed. Longitudinal cluster-based methods may provide novel insights in the study of
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction (Publications)
RATIONALE: Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known. OBJECTIVES: Perfor
What physical activity surveillance needs: validity of a single-item questionnaire (Publications)
BACKGROUND: Self-report instruments to assess physical activity are still the most feasible option in many population-wide surveys, and often need to be very short owing to resource constraints. The a
A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample (Publications)
RATIONALE: Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations i
Is diabetes a risk factor for a severe clinical presentation of dengue? Review and meta-analysis (Publications)
BACKGROUND: The mean age of acute dengue has undergone a shift towards older ages. This fact points towards the relevance of assessing the influence of age-related comorbidities, such as diabetes, on
The relevance of commuter and work/school exposure in an epidemiological study on traffic-related air pollution (Publications)
Exposure during transport and at non-residential locations is ignored in most epidemiological studies of traffic-related air pollution. We investigated the impact of separately estimating NO2 long-ter