Discovery and structure-activity relationships of quinazolinone-2-carboxamide derivatives as novel orally efficacious antimalarials (Publications)
A phenotypic high-throughput screen allowed discovery of quinazolinone-2-carboxamide derivatives as a novel antimalarial scaffold. Structure-activity relationship studies led to identification of a po
The effect of exposure to radiofrequency fields on cancer risk in the general and working population: a protocol for a systematic review of human... (Publications)
BACKGROUND: The World Health Organization (WHO) has an ongoing project to assess potential health effects of exposure to radiofrequency electromagnetic fields (RF-EMF) in the general and working popul
Access to water and sanitation infrastructures for primary schoolchildren in the south-central part of Côte d’Ivoire (Publications)
In rural settings of Côte d’Ivoire, access to water, sanitation, and hygiene (WASH) at schools is often lacking. The purpose of this study was to assess the availability, quality, and use of WASH infr
Identification of the asymptomatic <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> gametocyte reservoir under different transmission... (Publications)
BACKGROUND: Understanding epidemiological variables affecting gametocyte carriage and density is essential to design interventions that most effectively reduce malaria human-to-mosquito transmission.
Implementation of a non-communicable disease clinic in rural Sierra Leone: early experiences and lessons learned (Publications)
This study is an evaluation of the first cohort of patients enrolled in an outpatient non-communicable disease clinic in Kono, Sierra Leone. In the first year, the clinic enrolled 916 patients. Eight
Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not... (Publications)
The Mycobacterium ulcerans exotoxin, mycolactone, is responsible for the immunosuppression and tissue necrosis that characterizes Buruli ulcer. Mycolactone inhibits SEC61-dependent co-translational tr
Moderate-to-vigorous physical activity is associated with cardiorespiratory fitness among primary schoolchildren living in Côte d'Ivoire, South... (Publications)
Background: Physical inactivity and low cardiorespiratory fitness (CRF) are independent cardiovascular risk factors among children, but have rarely been investigated concurrently in sub-Saharan Africa
Low sensitivity of real time PCRs targeting retrotransposon sequences for the detection of <em>Schistosoma japonicum </em>complex DNA in human serum (Publications)
While hybridization probe-based real-time PCR assays targeting highly repetitive multi-copy genome sequences for the diagnosis of S. mansoni complex or S. haematobium complex from human serum are well
Long-term neurological and psychological distress symptoms among smallholder farmers in Costa Rica with a history of acute pesticide poisoning (Publications)
Studies suggest that acute pesticide poisonings (APP) may be linked with long-term neurological effects. To examine long-term neurological and psychological distress symptoms associated with having ex
Perception of cure among leprosy patients post completion of multi-drug therapy (Publications)
BACKGROUND: Leprosy is a treatable disease; however, the release from treatment after completion of multidrug therapy (MDT) often does not equal absence of health problems. Consequently, sequelae inte