Isothermal microcalorimetry, a new tool to monitor drug action against <em>Trypanosoma brucei</em> and <em>Plasmodium falciparum</em> (Publications)
Isothermal microcalorimetry is an established tool to measure heat flow of physical, chemical or biological processes. The metabolism of viable cells produces heat, and if sufficient cells are present
Bayesian geostatistical modeling of leishmaniasis incidence in Brazil (Publications)
BACKGROUND: Leishmaniasis is endemic in 98 countries with an estimated 350 million people at risk and approximately 2 million cases annually. Brazil is one of the most severely affected countries. MET
Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism (Publications)
BACKGROUND AND METHODOLOGY: Recently, we reported on a new class of naphthoquinone derivatives showing a promising anti-trypanosomatid profile in cell-based experiments. The lead of this series (B6, 2
Community-based surveillance of malaria vector larval habitats: a baseline study in urban Dar es Salaam, Tanzania (Publications)
ABSTRACT: BACKGROUND: As the population of Africa rapidly urbanizes it may be possible to protect large populations from malaria by controlling aquatic stages of mosquitoes. Here we present a baseline
A new double-antibody sandwich ELISA targeting <em>Plasmodium falciparum</em> aldolase to evaluate anti-malarial drug sensitivity (Publications)
BACKGROUND: The standard in vitro test to assess anti-malarial activity of chemical compounds is the [3H]hypoxanthine incorporation assay. It is a radioactivity-based method to measure DNA replication
A research agenda for malaria eradication: vector control (Publications)
Different challenges are presented by the variety of malaria transmission environments present in the world today. In each setting, improved control for reduction of morbidity is a necessary first ste
Couple experiences of provider-initiated couple HIV testing in an antenatal clinic in Lusaka, Zambia: lessons for policy and practice (Publications)
BACKGROUND: Couple HIV testing has been recognized as critical to increase uptake of HIV testing, facilitate disclosure of HIV status to marital partner, improve access to treatment, care and support,
Advancing drug innovation for neglected diseases-criteria for lead progression (Publications)
The current drug R&D pipeline for most neglected diseases remains weak, and unlikely to support registration of novel drug classes that meet desired target product profiles in the short term. This cal
Interpreting malaria age-prevalence and incidence curves: a simulation study of the effects of different types of heterogeneity (Publications)
ABSTRACT: BACKGROUND: Individuals in a malaria endemic community differ from one another. Many of these differences, such as heterogeneities in transmission or treatment-seeking behaviour, affect mala