Evaluating the effectiveness of IPTi on malaria using routine health information from sentinel health centres in southern Tanzania (Publications)
BACKGROUND: Intermittent preventive treatment of malaria in infants (IPTi) consists of the administration of a treatment dose of sulphadoxine-pyrimethamine (SP) at the time of routine vaccinations. Th
Rapid urban malaria appraisal (RUMA) I: Epidemiology of urban malaria in Ouagadougou (Publications)
BACKGROUND: Rapid urbanization in sub-Saharan Africa has a major impact on malaria epidemiology. While much is known about malaria in rural areas in Burkina Faso, the urban situation is less well unde
Rapid urban malaria appraisal (RUMA) in sub-Saharan Africa (Publications)
BACKGROUND: The rapid urban malaria appraisal (RUMA) methodology aims to provide a cost-effective tool to conduct rapid assessments of the malaria situation in urban sub-Saharan Africa and to improve
No <em>Paragonimus</em> in high-risk groups in Côte d'Ivoire, but considerable prevalence of helminths and intestinal protozoon infections (Publications)
ABSTRACT: BACKGROUND: Paragonimiasis is a neglected tropical disease caused by an infection with lung flukes that is transmitted through the consumption of undercooked crabs. The disease is often conf
Isothermal microcalorimetry, a new tool to monitor drug action against <em>Trypanosoma brucei</em> and <em>Plasmodium falciparum</em> (Publications)
Isothermal microcalorimetry is an established tool to measure heat flow of physical, chemical or biological processes. The metabolism of viable cells produces heat, and if sufficient cells are present
Bayesian geostatistical modeling of leishmaniasis incidence in Brazil (Publications)
BACKGROUND: Leishmaniasis is endemic in 98 countries with an estimated 350 million people at risk and approximately 2 million cases annually. Brazil is one of the most severely affected countries. MET
Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism (Publications)
BACKGROUND AND METHODOLOGY: Recently, we reported on a new class of naphthoquinone derivatives showing a promising anti-trypanosomatid profile in cell-based experiments. The lead of this series (B6, 2
Community-based surveillance of malaria vector larval habitats: a baseline study in urban Dar es Salaam, Tanzania (Publications)
ABSTRACT: BACKGROUND: As the population of Africa rapidly urbanizes it may be possible to protect large populations from malaria by controlling aquatic stages of mosquitoes. Here we present a baseline
A new double-antibody sandwich ELISA targeting <em>Plasmodium falciparum</em> aldolase to evaluate anti-malarial drug sensitivity (Publications)
BACKGROUND: The standard in vitro test to assess anti-malarial activity of chemical compounds is the [3H]hypoxanthine incorporation assay. It is a radioactivity-based method to measure DNA replication