Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase (Publications)
We report the discovery of novel uracil-based acyclic compounds as inhibitors of deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase), an enzyme involved in nucleotide metabolism that has been i
Novel inhibitors of leishmanial dihydrofolate reductase (Publications)
The program DOCK3.5 was used to search the Cambridge Structural Database for novel inhibitors of Leishmanial dihydrofolate reductase. A number of compounds were obtained and screened against the enzym
Quinuclidine derivatives as potential antiparasitics (Publications)
There is an urgent need for the development of new drugs for the treatment of tropical parasitic diseases such as Chagas' disease and leishmaniasis. One potential drug target in the organisms that cau
The contribution of health-care services to a sound and sustainable malaria-control policy (Publications)
HIV and AIDS, tuberculosis, and malaria, besides presenting a large mortality and morbidity burden in developing countries, are also responsible for poor economic development. In the past internationa