Impact of malaria pre-exposure on anti-parasite cellular and humoral immune responses after controlled human malaria infection (Publications)
To understand the effect of previous malaria exposure on anti-parasite immune responses is important for developing successful immunization strategies. Controlled human malaria infections (CHMI) using
Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents (Publications)
The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent
Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against... (Publications)
BACKGROUND: Existing anthelmintic drugs (eg, albendazole and mebendazole) have low efficacy against the intestinal nematode species Trichuris trichiura and the drug pipeline is exhausted. We aimed to
Repurposing of the open access malaria box for kinetoplastid diseases identifies novel active scaffolds against trypanosomatids (Publications)
Phenotypic screening had successfully been used for hit generation, especially in the field of neglected diseases, in which feeding the drug pipeline with new chemotypes remains a constant challenge.
Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for... (Publications)
BACKGROUND: Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In th