Structure-activity relationships for ferriprotoporphyrin IX association and beta-hematin inhibition by 4-aminoquinolines using experimental and <em>ab... (Publications)
In order to probe structure-activity relationships of association with ferriprotoporphyrin IX (logK) and inhibition of ?-hematin formation, a series of 4-aminoquinolines with varying substituents at t
Soil-transmitted helminth infection in South America: a systematic review and geostatistical meta-analysis (Publications)
BACKGROUND: The four common soil-transmitted helminth species-Ascaris lumbricoides, Trichuris trichiura, and the two hookworm species Ancylostoma duodenale and Necator americanus-are endemic in South
Deterrents to HIV-patient initiation of antiretroviral therapy in urban Lusaka, Zambia: a qualitative study (Publications)
Abstract Some people living with HIV (PLHIV) refuse to initiate antiretroviral therapy (ART) despite availability. Between March 2010 and September 2011, using a social ecological framework, we invest
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and... (Publications)
To ascertain the structure-activity relationship of the core 1,2,4-trioxolane substructure of dispiro ozonides OZ277 and OZ439, we compared the antimalarial activities and ADME profiles of the 1,2-dio
Timeliness and completeness of vaccination and risk factors for low and late vaccine uptake in young children living in rural southern Tanzania (Publications)
Background: We studied coverage and timeliness of vaccination and risk factors for low and delayed vaccine uptake in children aged ,2 years in rural Tanzania. Methods: We used data from a cluster surv
The baby-friendly hospital initiative in Switzerland: trends over a 9-year period (Publications)
Background:This article reports the trends over a 9-year period for 4 steps of the Baby-Friendly Hospital Initiative (BFHI) (exclusive breastfeeding, uninterrupted rooming-in, no use of pacifiers, and
Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal... (Publications)
The cysteine protease rhodesain of Trypanosoma brucei parasites causing African sleeping sickness has emerged as a target for the development of new drug candidates. Based on a triazine nitrile moiety