The genetic architecture of type 2 diabetes (Publications)
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association st
Discovery of antischistosomal drug leads based on tetraazamacrocyclic derivatives and their metal complexes (Publications)
Praziquantel (PZQ) is the only available drug to treat schistosomiasis, and since its large scale use might be associated with the onset of resistance, new antischistosomal drugs should be developed.
School distribution as keep-up strategy to maintain universal coverage of long-lasting insecticidal nets: implementation and results of a program in... (Publications)
Tanzania successfully scaled up coverage of long-lasting insecticidal nets (LLINs) through mass campaigns. To sustain these gains, a school-based approach was piloted in the country's Southern Zone st
Successful comeback of the single-dose live oral cholera vaccine CVD 103-HgR (Publications)
Effective and easy to administer cholera vaccines are in need more than ever, for at risk populations and travellers alike. In many parts of the world cholera is still endemic, causing outbreaks and c
Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections (Publications)
BACKGROUND: Treatment options for infections with soil-transmitted helminths (STH) - Ascaris lumbricoides, Trichuris trichiura and the two hookworm species, Ancylostoma duodenale and Necator americanu
Transdisciplinary research on cancer-healing systems between biomedicine and the Maya of Guatemala: a tool for reciprocal reflexivity in a... (Publications)
Transdisciplinarity (TD) is a participatory research approach in which actors from science and society work closely together. It offers means for promoting knowledge integration and finding solutions
Strengthening post-graduate educational capacity for health policy and systems research and analysis: the strategy of the Consortium for Health Policy... (Publications)
BACKGROUND: The last 5-10 years have seen significant international momentum build around the field of health policy and systems research and analysis (HPSR?+?A). Strengthening post-graduate teaching
Respiratory hospital admission risk near large composting facilities (Publications)
BACKGROUND: Large-scale composting can release bioaerosols in elevated quantities, but there are few studies of health effects on nearby communities. METHODS: A cross-sectional ecological small area d
A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes (Publications)
Human African trypanosomiasis (sleeping sickness) is a neglected tropical disease caused by Trypanosoma brucei spp. The parasites are transmitted by tsetse flies and adapt to their different hosts and
Novel nucleoside-based antimalarial compounds (Publications)
The malaria-causing parasite Plasmodium falciparum employs a salvage pathway for the biosynthesis of nucleotides, in contrast to de novo biosynthesis that is utilized by the human host. A series of tw