Identification and differentiation of <em>Leishmania</em> species in clinical samples by PCR amplification of the miniexon sequence and subsequent... (Publications)
We recently developed a new PCR-restriction fragment length polymorphism (RFLP)-based assay using the miniexon sequence from the genus LEISHMANIA: Here we report the application of this new genotyping
Synthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones (Publications)
Chagas' disease, caused by Trypanosoma cruzi(T. cruzi), is one of the most serious parasitic diseases in Latin America. The currently available chemotherapy, based on nifurtimox or benznidazole, is un
<em>Schistosoma mansoni</em>: antischistosomal activity of the four optical isomers and the two racemates of mefloquine on schistosomula and adult... (Publications)
Recent studies have shown that mefloquine (MQ) reveals interesting antischistosomal properties. We examined the antischistosomal activities of the erythro and threo isomers and racemates of MQ on newl
The complete mitochondrial genome of the rodent intra-arterial nematodes <em>Angiostrongylus cantonensis</em> and <em>Angiostrongylus... (Publications)
The two rodent intra-arterial nematodes, Angiostrongylus cantonensis and Angiostrongylus costaricensis, can cause human ill-health. The present study aimed to characterize and compare the mitochondria
Mortality due to Chagas disease in Brazil from 1979 to 2009: trends and regional differences (Publications)
INTRODUCTION: Studies on mortality due to parasitic diseases such as Chagas disease are useful to understand the epidemiology and to plan and guide control measures for these diseases. We analyzed mor
Pouched rats' detection of tuberculosis in human sputum: comparison to culturing and polymerase chain reaction (Publications)
Setting. Tanzania. Objective. To compare microscopy as conducted in direct observation of treatment, short course centers to pouched rats as detectors of Mycobacterium tuberculosis. Design. Ten pouche
<em>In vitro</em> assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of <em>Plasmodium falciparum</em> (Publications)
OBJECTIVES: Using synchronous cultures of Plasmodium falciparum malaria, the stage sensitivity of the parasite to OZ277 (RBx-11160), the first fully synthetic antimalarial peroxide that has entered Ph
An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from <em>Eupatorium perfoliatum</em> (Publications)
The CH(2)Cl(2) extract of aerial parts of Eupatorium perfoliatum L. exhibits antiprotozoal activity under in vitro conditions, especially against Plasmodium falciparum (IC(50)=2.7mug/ml). The search f