Abietane-type diterpenoid amides with highly potent and selective activity against <em>Leishmania donovani</em> and <em>Trypanosoma cruzi</em> (Publications)
Dehydroabietylamine (1) was used as a starting material to synthesize a small library of dehydroabietyl amides by simple and facile methods, and their activities against two disease-causing trypanosom
Independent at heart: persistent association of altitude with ischaemic heart disease mortality after consideration of climate, topography and built... (Publications)
BACKGROUND: Living at higher altitude was dose-dependently associated with lower risk of ischaemic heart disease (IHD). Higher altitudes have different climatic, topographic and built environment prop
Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients (Publications)
OBJECTIVES: SQ109, an asymmetrical diamine, is a novel anti-TB drug candidate. This first study in patients was done to determine safety, tolerability, pharmacokinetics and bacteriological effect of d
Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled,... (Publications)
BACKGROUND: The ongoing Ebola outbreak led to accelerated efforts to test vaccine candidates. On the basis of a request by WHO, we aimed to assess the safety and immunogenicity of the monovalent, reco
Population genomics of <em>Mycobacterium tuberculosis</em> in Ethiopia contradicts the virgin soil hypothesis for human tuberculosis in sub-Saharan... (Publications)
Colonial medical reports claimed that tuberculosis (TB) was largely unknown in Africa prior to European contact, providing a "virgin soil" for spread of TB in highly susceptible populations previously
The prevalence of syphilis infection and its associated factors in the general population of Rwanda: a national household-based survey (Publications)
Background. The prevalence of syphilis among HIV-infected people is a public health concern, but there is limited literature to describe the true burden of syphilis in resource-limited settings. We co
Ambiguous care: siblings and the economies of HIV-related care in Zambia (Publications)
While kinship used to be considered a backbone of the creation of mutual obligations for care in pre-industrial societies, economic and social change has altered how care is provided. Notwithstanding
How to evaluate health-related quality of life and its association with medication adherence in pulmonary tuberculosis - designing a prospective... (Publications)
INTRODUCTION: Health-related quality of life (HRQOL) has become an important measure to identify and shape effective and patient-relevant healthcare interventions innovations through outcomes. Adheren