Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant <em>Plasmodium falciparum</em>... (Publications)
Plasmodium falciparum, the most deadly malaria agent, displays a wide variety of resistance mechanisms in the field. The ability of antimalarial compounds in development to overcome these must therefo
The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data (Publications)
BACKGROUND: Artemether-lumefantrine is the most widely used artemisinin-based combination therapy for malaria, although treatment failures occur in some regions. We investigated the effect of dosing s
Long-term exposure to particulate matter constituents and the incidence of coronary events in 11 European cohorts (Publications)
BACKGROUND: Long-term exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity and mortality but little is known about the role of the chemical composition of PM
Using lung cancer mortality to indirectly approximate smoking patterns in space (Publications)
Smoking is the leading cause of lung cancer. Non-smoking factors have been associated with the disease. Existing Swiss survey data only capture the country partially and temporal coverage does not all
Antiviral innate immune activation in HIV infected adults negatively affects H1/IC31(R) induced vaccine-specific memory CD4+ T cells (Publications)
Tuberculosis (TB) remains a global health problem, with vaccination being a necessary strategy for disease containment and elimination. A TB vaccine should be safe and immunogenic as well as efficacio
Human African trypanosomiasis prevention, treatment and control costs: a systematic review (Publications)
The control and eventual elimination of human African trypanosomiasis (HAT) requires the expansion of current control and surveillance activities. A systematic review of the published literature on th
Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3,... (Publications)
BACKGROUND: The efficacy and safety of the RTS,S/AS01 candidate malaria vaccine during 18 months of follow-up have been published previously. Herein, we report the final results from the same trial, i
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria (Publications)
Malaria is one of the most significant causes of childhood mortality, but disease control efforts are threatened by resistance of the Plasmodium parasite to current therapies. Continued progress in co
Are well functioning civil registration and vital statistics systems associated with better health outcomes? (Publications)
In this Series paper, we examine whether well functioning civil registration and vital statistics (CRVS) systems are associated with improved population health outcomes. We present a conceptual model