The lipid-modifying enzyme SMPDL3B negatively regulates innate immunity (Publications)
Lipid metabolism and receptor-mediated signaling are highly intertwined processes that cooperate to fulfill cellular functions and safeguard cellular homeostasis. Activation of Toll-like receptors (TL
Civil registration and vital statistics: progress in the data revolution for counting and accountability (Publications)
New momentum for civil registration and vital statistics (CRVS) is building, driven by the confluence of growing demands for accountability and results in health, improved equity, and rights-based app
Towards a framework for evaluating and grading evidence in public health (Publications)
The Project on a Framework for Rating Evidence in Public Health (PRECEPT) is an international collaboration of public health institutes and universities which has been funded by the European Centre fo
Genomic epidemiology of multidrug-resistant <em>Mycobacterium tuberculosis</em> during transcontinental spread (Publications)
The transcontinental spread of multidrug-resistant (MDR) tuberculosis is poorly characterized in molecular epidemiologic studies. We used genomic sequencing to understand the establishment and dispers
Associations between particulate matter composition and childhood blood pressure - the PIAMA study (Publications)
BACKGROUND: Childhood blood pressure is an important predictor of hypertension and cardiovascular disease in adulthood. Evidence for an association between ambient particulate matter (PM) exposure and
Investigating the potential of reported cattle mortality data in Switzerland for syndromic surveillance (Publications)
Systems for the identification and registration of cattle have gradually been receiving attention for use in syndromic surveillance, a relatively recent approach for the early detection of infectious
Determinants of virological failure and antiretroviral drug resistance in Mozambique (Publications)
OBJECTIVES: The objective of this study was to inform public health actions to limit first-line ART failure and HIV drug resistance in Mozambique. METHODS: This was a cross-sectional study. HIV-1-infe
Macyranones: structure, biosynthesis, and binding mode of an unprecedented epoxyketone that targets the 20S proteasome (Publications)
In our screening efforts to identify unique scaffolds from myxobacteria for the drug discovery process, we used LC-SPE-NMR-MS techniques to isolate six linear peptides, termed macyranone A-F, from Cys
A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes (Publications)
Discovery of novel drug targets may lead to improved treatment of trypanosomiasis. We characterize here 2 gene products of Trypanosoma brucei that are essential for the growth of bloodstream form para