6-Arylpyrazine-2-carboxamides: a new core for <em>Trypanosoma brucei</em> inhibitors (Publications)
From a whole-organism high throughput screen of approximately 87,000 compounds against Trypanosoma brucei brucei, we recently identified eight new unique compounds for the treatment of human African t
Transport-related measures to mitigate climate change in Basel, Switzerland: a health-effectiveness comparison study (Publications)
BACKGROUND: Local strategies to reduce green-house gases (GHG) imply changes of non-climatic exposure patterns. OBJECTIVE: To assess the health impacts of locally relevant transport-related climate ch
Meta-analysis identifies seven susceptibility loci involved in the atopic march (Publications)
Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage
Pharmacological effects of primaquine ureas and semicarbazides on the CNS in mice and antimalarial activity in vitro (Publications)
New primaquine (PQ) urea and semicarbazide derivatives 1-4 were screened for the first time for CNS and antimalarial activity. Behavioural tests were performed on mice. In vitro cytotoxicity on L-6 ce
The elderly, the young and the pregnant traveler - a retrospective data analysis from a large Swiss Travel Center with a special focus on malaria... (Publications)
BACKGROUND: Vulnerable individuals such as elderly, children/adolescents and pregnant/breastfeeding women increasingly travel overseas. We describe the travel and vaccination patterns of these groups
Costing RTS,S introduction in Burkina Faso, Ghana, Kenya, Senegal, Tanzania, and Uganda: a generalizable approach drawing on publicly available data (Publications)
Recent results from the phase 3 trial of RTS,S/AS01 malaria vaccine show that the vaccine induced partial protection against clinical malaria in infants and children; given the high burden of the dise
Evaluation of banked urine samples for the detection of circulating anodic and cathodic antigens in <em>Schistosoma mekongi </em>and <em>S. japonicum... (Publications)
In Asia, Schistosoma japonicum is the predominant schistosome species, while Schistosoma mekongi is confined to limited foci in Cambodia and Lao People's Democratic Republic. While the People's Republ
Repeated stool sampling and use of multiple techniques enhance the sensitivity of helminth diagnosis: a cross-sectional survey in southern Lao... (Publications)
Intestinal parasitic infections are common in Lao People's Democratic Republic (Lao PDR). We investigated the accuracy of the Kato-Katz (KK) technique in relation to varying stool sampling efforts, an