Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood (Publications)
BACKGROUND: European cross-sectional studies have suggested that prenatal and postnatal farm exposure decreases the risk of allergic diseases in childhood. Underlying immunologic mechanisms are still
Progress in research, control and elimination of helminth infections in Asia (Publications)
Global health has substantially improved over the past 20 years. In low- and middle-income countries, in particular, great strives have been made in the control of communicable diseases, including hel
Multiparasitism and intensity of helminth infections in relation to symptoms and nutritional status among children: a cross-sectional study in... (Publications)
The occurrence and spatial distribution of intestinal helminth infection in children is fairly well understood. However, knowledge on how helminth infections govern intestinal morbidity is scarce. We
Isothermal microcalorimetry accurately detects bacteria, tumorous microtissues, and parasitic worms in a label-free well-plate assay (Publications)
Isothermal microcalorimetry is a label-free assay that allows monitoring of enzymatic and metabolic activities. The technique has strengths, but most instruments have a low throughput, which has limit
Evolutionary history and global spread of the <em>Mycobacterium tuberculosis</em> Beijing lineage (Publications)
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructe
Antiprotozoal activity and DNA binding of dicationic acridones (Publications)
Dicationic acridone derivatives were synthesized and their antiparasitic activity was evaluated. Acridones displayed in vitro nanomolar IC50 values against Trypanosoma brucei rhodesiense STIB900 with
Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents (Publications)
3-Nitro-1H-1,2,4-triazole-based amides with a linear, rigid core and 3-nitrotriazole-based fluconazole analogues were synthesized as dual functioning antitrypanosomal agents. Such compounds are excell
Effect of long-term outdoor air pollution and noise on cognitive and psychological functions in adults (Publications)
It has been hypothesized that air pollution and ambient noise might impact neurocognitive function. Early studies mostly investigated the associations of air pollution and ambient noise exposure with
Conducting an audit to improve the facilitation of emergency maternal and newborn referral in northern Ghana (Publications)
Ghana Health Service conducted an audit to strengthen the referral system for pregnant or recently pregnant women and newborns in northern Ghana. The audit took place in 16 facilities with two 3-month
Tracking a tuberculosis outbreak over 21 years: strain-specific single nucleotide polymorphism-typing combined with targeted whole genome sequencing (Publications)
BACKGROUND: Whole genome sequencing (WGS) is increasingly used in molecular-epidemiological investigations of bacterial pathogens, despite cost- and time-intensive analyses. We combined strain-specifi