Novel 3-nitro-1<em>H</em>-1,2,4-triazole-based piperazines a nd 2-amino-1,3-benzothiazoles as antichagasic agents (Publications)
We have previously shown that 3-nitro-1H-1,2,4-triazole-based amines demonstrate significant trypanocidal activity, in particular against Trypanosoma cruzi, the causative parasite of Chagas disease. I
Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives (Publications)
4,4''-Diamidino-m-terphenyl (1) and 36 analogues were prepared and assayed in vitro against T rypanosoma brucei rhodesiense , Trypanosoma cruzi , Plasmodium falciparum , and Leishmania amazonensis . T
Nonrandomized controlled trial of artesunate plus sulfadoxine-pyrimethamine with or without primaquine for preventing posttreatment circulation of... (Publications)
Artemisinin combination therapies eliminate immature Plasmodium falciparum gametocytes but not mature gametocytes, which may persist for up to 1 month posttreatment. A single dose of primaquine, which
Antigenicity and immunogenicity of a novel chimeric peptide antigen based on the <em>P. vivax</em> circumsporozoite protein (Publications)
BACKGROUND: Plasmodium vivax circumsporozoite (PvCS) protein is a major sporozoite surface antigen involved in parasite invasion of hepatocytes and is currently being considered as vaccine candidate.
UV-triggered affinity-capture identifies interactions between the <em>Plasmodium falciparum</em> multidrug resistance protein 1 (PfMDR1) and... (Publications)
A representative of a new class of potent antimalarials with an unknown mode of action was recently described. To identify the molecular target of this class of antimalarials, we employed a photo-reac
Antiprotozoal screening of 60 south African plants, and the identification of the antitrypanosomal germacranolides schkuhrin I and II (Publications)
Two hundred and seven extracts were prepared from sixty plants from South Africa and screened for in vitro activity against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and
Concentrations of urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane in women exposed to woodsmoke in a cookstove intervention study in San Marcos,... (Publications)
Nearly half of the world's population is exposed to household air pollution (HAP) due to long hours spent in close proximity to unvented cooking fires. The effect of woodsmoke exposure on oxidative st
Genomic analysis identifies targets of convergent positive selection in drug-resistant <em>Mycobacterium tuberculosis</em> (Publications)
M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis epidemic control. Mechanisms of resistance, including genetic changes favored by selection in resistant isolates