Unit | Disease Modelling

Core to our modelling work is the development and use of an individual-based model of malaria transmission dynamics known as OpenMalaria. This model is an open-source tool for simulating the dynamics of malaria transmission and epidemiology, and the impact of interventions on health and economic outcomes. The model can simulate malaria in village or district size human populations, and has been used to address questions on disease dynamics and the use of interventions. Developed and maintained by the Disease Modelling Unit of Swiss TPH, our OpenMalaria model is used by a wide range of modellers worldwide. A new collaboration with the Bill & Melinda Gates Foundation supports the improvement and maintenance of OpenMalaria as well as the development of new mathematical malaria models. This project will provide model-based evidence for the Foundation and key partners towards improved investment and decision-making for better malaria control and elimination. Read more

There has been substantial progress in reducing malaria transmission in the Greater Mekong Subregion. However, progress has stalled with reports of increase in the number of cases, multidrug-resistant malaria, and pyrethroid-resistant mosquitoes. The risk of infection is greatest among mobile and migrant populations. Many of the dominant malaria vectors in this subregion feed and rest outdoors, yet there is limited available protection against mosquito biting outdoors for at-risk populations. To address these pressing challenges, the University of California, San Francisco, Malaria Elimination Initiative in partnership with the University of Notre Dame, IVCC, Swiss TPH, and a consortium of project partners propose to evaluate new vector control tools that aim to reduce human exposure to mosquito bites outdoors. Read more